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No, I won't calm down.
 
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Below are the 12 most recent journal entries recorded in spamjavelin's LiveJournal:

    Monday, May 12th, 2008
    3:30 pm
    Comedy gold.......

    .......of the variety only found in Belfast. Ladies and Genitalmentals, the comedy stylings of Mr. Michael Stone: http://news.bbc.co.uk/2/hi/uk_news/northern_ireland/7395475.stm

    Scarily, he looks like half my friends and relatives. The joys of a gene puddle....................

    Sunday, January 13th, 2008
    2:32 pm
    "The more things change..........

    .................the more they stay the same. We can't grow if we won't criticise ourselves" (thanks Jello B.)

    You know, just when I am telling the wortld how much things have improved and how Belfast is great now:

    http://observer.guardian.co.uk/uk_news/story/0,,2239941,00.html

    This kind of shit comes back to haunt me. This never-changing sub-culture is why I find it hard to stay at home for more than a week. Depressing.

    This is why, in my own home town, there are only maybe 3 bars  I'll go into for more than one drink. (really only one for a full night and surprise:the only catholic bar). Most of them I wouldn't even take Tarts into for fear someone will start asking about her background/who I am/why we are both a bit 'Fenian Lookin' etc.

    Bert said over christmas that the longer he lives in N.I., the more alien/Canadian he feels. I agreed and said I feel the same, but it only just struck me how he can still be Canadian, but that leaves me with nothing................

    Wednesday, March 28th, 2007
    6:37 pm
    Duck noises in oncology investigations?
    The current debate over pharma has stimulated my wish to use this as a forum for scientific geekery/policy discussion. Things just got a lot more complicated on the DCA front:

    http://www.newscientist.com/article.ns?id=mg19325973.800&feedId=online-news_rss20

    This could run and run kiddies. Even though I was wrong in my initial assumtion and the investigators are clearly not quacks, the quacks have now come to call. Opinions?
    Friday, March 23rd, 2007
    5:10 pm
    Not dead yet
    I'm not dead yet.............I am just lost up my own rectum. Apologies to everyone I have lost contact with recently. I left the crap job cos I got a good one, but am now working like a lunatic and traveling all the time. Excuses, excuses...........

    But this is an open up thread for Scheck,  et al. to have their say on my post on a certain Telie's site. Have at you!

    Current Mood: tired
    Sunday, March 26th, 2006
    11:42 pm
    Name that tune in one!
    If I were a classic punk song I would be paraphrased to start thusly:

    'I get drunk a lot and work 70 hours a week'.

    Can anyone name that tune and also tell me WHY I work 70 hours a week for a job with no future and for people who value me somewhere below their own hemorrhoids?

    Seriously, maybe Spunkmunky might be able to illuminate what went horribly wrong in my childhood to cause me to do this for a living?
    Sunday, January 22nd, 2006
    7:00 pm
    Morales
    The Evo Morales sweepstakes begin today! Get your prediction on how long his assasination/co-option/milatary coup will take!

    I give him 3 months. The 'Company' hasn't left since they had Che Guevara 'eliminated' there. Come to think of it, how much more time will Hugo Chavez have?!

    Current Mood: pessimistic
    Wednesday, November 16th, 2005
    10:54 am
    Wow, here's a shock kiddies: maybe the democratic idyll installed by our 'regime change' will be just the same as when Sodamn Insane was in power! OOps! How the fuck did thast happen?

    http://www.guardian.co.uk/Iraq/Story/0,2763,1643563,00.html
    Monday, July 11th, 2005
    4:44 pm
    One more before I go, on the below theme:

    Food groups and colorectal cancer risk

    F Levi1, et al. 1998.

    Most studies of diet and colorectal cancer have considered nutrients and micronutrients, but the role of foods or food groups remains open to debate. To elucidate the issue, we examined data from a case-control study conducted between 1992 and 1997 in the Swiss canton of Vaud. Cases were 223 patients (142 men, 81 women) with incident, histologically confirmed colon (n = 119) or rectal (n = 104) cancer (median age 63 years), linked with the Cancer Registry of the Swiss Canton of Vaud, and controls were 491 subjects (211 men, 280 women, median age 58 years) admitted to the same university hospital for a wide spectrum of acute non-neoplastic conditions unrelated to long-term modifications of diet. Odds ratios (OR) were obtained after allowance for age, sex, education, smoking, alcohol, body mass index, physical activity and total energy intake. Significant associations were observed for refined grain (OR = 1.32 for an increase of one serving per day), and red meat (OR = 1.54), pork and processed meat (OR = 1.27), alcohol (OR = 1.28), and significant protections for whole grain (OR = 0.85), raw (OR = 0.85) and cooked vegetables (OR = 0.69), citrus (OR = 0.86) and other fruits (OR = 0.85), and for coffee (OR = 0.73). Garlic was also protective (OR = 0.32 for the highest tertile of intake). These findings in a central European population support the hypothesis that a diet rich in refined grains and red meat increases the risk of colorectal cancer; they, therefore, support the recommendation to substitute whole grains for refined grain, to limit meat intake, and to increase fruit and vegetable consumption.
    © 1999 Cancer Research Campaign


    I think it's important that people realise that these studies are numerous, rigorous and all point in one direction = Our Diets Are Bad.
    4:31 pm
    I'm not interesting.
    Obviously. But some of the things I read ARE. I have decided to use this space mostly as an info splurge to friends who might be interested.

    First two up: from the British Journal of cancer

    Soybean products and reduction of breast cancer risk: a case-control study in Japan

    K Hirose1 et al.
    Received 21 February 2005; revised 9 May 2005; accepted 9 May 2005; published online 7 June 2005



    Components of the Japanese diet, which might contribute to the relatively low breast cancer incidence rates in Japan, have not been clarified in detail. Since soybean products are widely consumed in Japan, a case-control study taking account of the menopausal status was conducted using data from the hospital-based epidemiologic research program at Aichi Cancer Center (HERPACC). In total, 167 breast cancer cases were included and 854 women confirmed as free of cancer were recruited as the control group. Odds ratios (OR) and 95% confidence intervals (95% CI) were determined by multiple logistic regression analysis. There were reductions in risk of breast cancer associated with high intake of soybean products among premenopausal women. Compared with women in the lowest tertile, the adjusted ORs for top tertile intake of tofu (soybean curd) was 0.49 (95% CI, 0.25-0.95). A significant decrease in premenopausal breast cancer risk was also observed for increasing consumption of isoflavones (OR=0.44; 95% CI, 0.22-0.89 for highest vs lowest tertile; P for trend=0.02). The present study found a statistically inverse association between tofu or isoflavone intake and risk of breast cancer in Japanese premenopausal women, while no statistically significant association was evident with the risk among postmenopausal women.


    Number two: also Br. J. Cancer.

    Garlic arrests MDA-MB-435 cancer cells in mitosis, phosphorylates the proapoptotic BH3-only protein BimEL and induces apoptosis

    T Lund1, T Stokke2, Ø E Olsen1 and Ø Fodstad1

    1Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo 0310, Norway

    2Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo 0310, Norway



    Correspondence to: Dr T Lund, E-mail: terjelu@radium.uio.no

    Revised 25 February 2005; accepted 28 February 2005; published online 12 April 2005



    Components of garlic (Allium sativum) can cause disruption of microtubules, cell cycle arrest, and apoptosis in cancer cells. We show here that a water-soluble extract of garlic arrested MDA-MB-435 cancer cells in mitosis and caused apoptosis. The proapoptotic BH3-only, bcl-2 family protein BimEL, which in healthy cells can be tightly sequestered to the microtubule-associated dynein motor complex, was modified after garlic treatment. The main effect of garlic on BimEL was a considerable increase in a phosphorylated form of the protein. This phosphorylation(s), probably partly dependent on c-jun N-terminal kinase activity, promoted mitochondrial localisation of BimEL. Furthermore, inhibition of extracellular signal-regulated kinases 1/2 increased the amount of another form of BimEL present in the mitochondrial cellular fraction. Treatment of cells with the garlic compound diallyl disulphide had similar effects on BimEL. The results indicate that the apoptotic effect of garlic and a combination of garlic and the inhibitor of extracellular signal-regulated kinases 1/2 in MDA-MB-435 cells partly is due to modifications that are necessary for translocation of the proapoptotic protein BimEL to mitochondria where it executes its proapoptotic function.


    These are both small, but highly interesting studies linking foods I like a lot, with decreased cancer risk, for men and women. Adding credence to the possibility that environmental toxic effects and endogenous cellular instabilities can be impacted positively by what we eat.

    Science is cool kiddies.

    Current Mood: tired
    Wednesday, June 15th, 2005
    11:17 pm
    Tagged
    My tunes:

    Mars Volta: Cignus...Vismund Cignus
    Nomeansno: Bitches brew
    Thin lizzy: The rocker
    Tracey Chapman: Let it rain
    mike Watt: Kids against the seventies
    Monday, February 28th, 2005
    5:03 pm
    Goodbye Liberace.
    Hello Ebeneezer Scrooge and dedicating my life to the polar opposite of what it has been until now: SAVING money.

    I know.............what will the publicans of Ireland do. Surely they are crying into their rapidly-flattening pints.

    MmmmmmmmmmmmmmmmmmmmmmmmmmmmISERLY!!!!!
    Wednesday, February 2nd, 2005
    5:20 pm
    Getting Started
    HA! Now I am a proper geek. I wonder who will realise it's me first?

    Current Mood: lethargic
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